Clinical Outcomes

Carson JL, Terrin ML, Noveck H, Sanders DW, Chaitman BR, Rhoads GG, Nemo G, Dragert K, Beaupre L, Hildebrand K, Macaulay W, Lewis C, Cook DR, Dobbin G, Zakriya KJ, Apple FS, Horney RA, Magaziner J; FOCUS Investigators.

Source‎: N Engl J Med 2011;365(26):2453-62.

Indexed‎: PubMed 22168590

DOI‎: 10.1056/NEJMoa1012452

https://www.ncbi.nlm.nih.gov/pubmed/22168590 (opens new window)

Association between bleeding events and in-hospital mortality after percutaneous coronary intervention. (opens new window)

Chhatriwalla AK, Amin AP, Kennedy KF, House JA, Cohen DJ, Rao SV, Messenger JC, Marso SP; National Cardiovascular Data Registry.

Source‎: JAMA 2013;309(10):1022-9.

Indexed‎: PubMed 23483177

DOI‎: 10.1001/jama.2013.1556

https://www.ncbi.nlm.nih.gov/pubmed/23483177 (opens new window)

How good patient blood management leads to excellent outcomes in Jehovah's Witness patients undergoing cardiac surgery. (opens new window)

Emmert MY, Salzberg SP, Theusinger OM, Felix C, Plass A, Hoerstrup SP, Falk V, Gruenenfelder J.

Source‎: Interact Cardiovasc Thorac Surg 2011;12(2):183-8.

Indexed‎: PubMed 20829389

DOI‎: 10.1510/icvts.2010.242552

https://www.ncbi.nlm.nih.gov/pubmed/20829389 (opens new window)

Effect of blood transfusion on long-term survival after cardiac operation. (opens new window)

Engoren MC, Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ.

Source‎: Ann Thorac Surg 2002;74(4):1180-6.

Indexed‎: PubMed 12400765

https://www.ncbi.nlm.nih.gov/pubmed/12400765 (opens new window)

Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration. (opens new window)

Frank SM, Abazyan B, Ono M, Hogue CW, Cohen DB, Berkowitz DE, Ness PM, Barodka VM.

Source‎: Anesth Analg 2013;116(5):975-81.

Indexed‎: PubMed 23449853

DOI‎: 10.1213/ANE.0b013e31828843e6

https://www.ncbi.nlm.nih.gov/pubmed/23449853 (opens new window)

Risk-adjusted clinical outcomes in patients enrolled in a bloodless program. (opens new window)

Frank SM, Wick EC, Dezern AE, Ness PM, Wasey JO, Pippa AC, Dackiw E, Resar LM.

Source‎: Transfusion 2014;54(10 Pt 2):2668-77.

Indexed‎: PubMed 24942198

DOI‎: 10.1111/trf.12752

https://www.ncbi.nlm.nih.gov/pubmed/24942198 (opens new window)

Blood transfusion in cardiac surgery is a risk factor for increased hospital length of stay in adult patients. (opens new window)

Galas FR, Almeida JP, Fukushima JT, Osawa EA, Nakamura RE, Silva CM, de Almeida EP, Auler JO, Vincent JL, Hajjar LA.

Source‎: J Cardiothorac Surg 2013;8:54.

Indexed‎: PubMed 23531208

DOI‎: 10.1186/1749-8090-8-54

https://www.ncbi.nlm.nih.gov/pubmed/23531208 (opens new window)

Optimizing safety and success: the advantages of bloodless cardiac surgery. A systematic review and meta-analysis of outcomes in Jehovah's Witnesses. (opens new window)

Gemelli M, Italiano EG, Geatti V, Addonizio M, Cao I, Dimagli A, Dokollari A, Tarzia V, Gallo M, Ferrari E, Slaughter MS, Gerosa G

Source‎: Curr Probl Cardiol. 2024 ;49(1 Pt B):102078.

Indexed‎: PubMed 37716536

DOI‎: 10.1016/j.cpcardiol.2023.102078

https://pubmed.ncbi.nlm.nih.gov/37716536/ (opens new window)

Restrictive blood transfusion practices are associated with improved patient outcomes. (opens new window)

Goodnough LT, Maggio P, Hadhazy E, Shieh L, Hernandez-Boussard T, Khari P, Shah N.

Source‎: Transfusion 2014;54(10 Pt 2):2753-9.

Indexed‎: PubMed 24995770

DOI‎: 10.1111/trf.12723

https://www.ncbi.nlm.nih.gov/pubmed/24995770 (opens new window)

Patient blood management in cardiac surgery results in fewer transfusions and better outcome. (opens new window)

Gross I, Seifert B, Hofmann A, Spahn DR.

Source‎: Transfusion 2015;55(5):1075-81.

Indexed‎: PubMed 25565302

DOI‎: 10.1111/trf.12946

https://www.ncbi.nlm.nih.gov/pubmed/25565302 (opens new window)

Costs and outcomes after cardiac surgery in patients refusing transfusion compared with those who do not: a case-matched study. (opens new window)

Guinn NR, Roberson RS, White W, Cowper PA, Broomer B, Milano C, Chiricolo A, Hill S.

Source‎: Transfusion 2015;55(12):2791-8.

Indexed‎: PubMed 26183817

DOI‎: 10.1111/trf.13246

https://www.ncbi.nlm.nih.gov/pubmed/26183817 (opens new window)

Blood transfusion and 30-day mortality in patients with coronary artery disease and anemia following noncardiac surgery. (opens new window)

Hollis RH, Singletary BA, McMurtrie JT, Graham LA, Richman JS, Holcomb CN, Itani KM, Maddox TM, Hawn MT.

Source‎: JAMA Surg 2016;151(2):139-45.

Indexed‎: PubMed 26444569

DOI‎: 10.1001/jamasurg.2015.3420

https://www.ncbi.nlm.nih.gov/pubmed/26444569 (opens new window)

Blood transfusion and infection after cardiac surgery. (opens new window)

Horvath KA, Acker MA, Chang H, Bagiella E, Smith PK, Iribarne A, Kron IL, Lackner P, Argenziano M, Ascheim DD, Gelijns AC, Michler RE, Van Patten D, Puskas JD, O'Sullivan K, Kliniewski D, Jeffries NO, O'Gara PT, Moskowitz AJ, Blackstone EH.

Source‎: Ann Thorac Surg 2013;95(6):2194-201.

Indexed‎: PubMed 23647857

DOI‎: 10.1016/j.athoracsur.2012.11.078

https://www.ncbi.nlm.nih.gov/pubmed/23647857 (opens new window)

Incidence and impact of a single-unit red blood cell transfusion: analysis of The Society of Thoracic Surgeons Database 2010-2019. (opens new window)

Ivascu Girardi N, Cushing MM, Evered LA, Benedetto U, Schwann TA, Kurlansky P, Habib RH, Gaudino MFL

Source‎: Ann Thorac Surg. 2023;115(4):1035-41. Epub 2022 Dec 15.

Indexed‎: PubMed 36528125

DOI‎: 10.1016/j.athoracsur.2022.11.037

https://pubmed.ncbi.nlm.nih.gov/36528125/ (opens new window)

Transfusion of blood during cardiac surgery is associated with higher long-term mortality in low-risk patients. (opens new window)

Jakobsen CJ, Ryhammer PK, Tang M, Andreasen JJ, Mortensen PE.

Source‎: Eur J Cardiothorac Surg 2012;42(1):114-20.

Indexed‎: PubMed 22241009

DOI‎: 10.1093/ejcts/ezr242

https://www.ncbi.nlm.nih.gov/pubmed/22241009 (opens new window)

Cardiac surgery in Jehovah's Witness patients: ten-year experience. (opens new window)

Jassar AS, Ford PA, Haber HL, Isidro A, Swain JD, Bavaria JE, Bridges CR.

Source‎: Ann Thorac Surg 2012;93(1):19-25.

Indexed‎: PubMed 21978873

DOI‎: 10.1016/j.athoracsur.2011.06.029

https://www.ncbi.nlm.nih.gov/pubmed/21978873 (opens new window)

Results of open heart surgery in Jehovah's Witnesses patients. (opens new window)

Juraszek A, Dziodzio T, Roedler S, Kral A, Hutschala D, Wolner E, Grimm M, Czerny M.

Source‎: J Cardiovasc Surg (Torino) 2009;50(2):247-50.

Indexed‎: PubMed 19329922

https://www.ncbi.nlm.nih.gov/pubmed/19329922 (opens new window)

Perioperative red blood cell transfusion is associated with adverse cardiovascular outcomes in heart valve surgery. (opens new window)

Kim HJ, Kim JE, Lee JY, Lee SH, Jung JS, Son HS

Source‎: Anesth Analg. 2023 1;137(1):153-61. Epub 2022 Nov 1.

Indexed‎: PubMed 36730895

DOI‎: 10.1213/ANE.0000000000006245

https://pubmed.ncbi.nlm.nih.gov/36730895/ (opens new window)

Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery. (opens new window)

LaPar DJ, Crosby IK, Ailawadi G, Ad N, Choi E, Spiess BD, Rich JB, Kasirajan V, Fonner E Jr, Kron IL, Speir AM; Investigators for the Virginia Cardiac Surgery Quality Initiative.

Source‎: J Thorac Cardiovasc Surg 2013;145(3):796-804.

Indexed‎: PubMed 23414992

DOI‎: 10.1016/j.jtcvs.2012.12.041

https://www.ncbi.nlm.nih.gov/pubmed/23414992 (opens new window)

Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery. (opens new window)

Leal-Noval SR, Rincón-Ferrari MD, García-Curiel A, Herruzo-Avilés A, Camacho-Laraña P, Garnacho-Montero J, Amaya-Villar R.

Source‎: Chest 2001;119(5):1461-8.

Indexed‎: PubMed 11348954

https://www.ncbi.nlm.nih.gov/pubmed/11348954 (opens new window)

Red blood cell transfusions impact pneumonia rates after coronary artery bypass grafting. (opens new window)

Likosky DS, Paone G, Zhang M, Rogers MA, Harrington SD, Theurer PF, DeLucia A 3rd, Fishstrom A, Camaj A, Prager RL; Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative.

Source‎: Ann Thorac Surg 2015;100(3):794-800.

Indexed‎: PubMed 26209489

DOI‎: 10.1016/j.athoracsur.2015.03.089

https://www.ncbi.nlm.nih.gov/pubmed/26209489 (opens new window)

The effect of universal leukoreduction on postoperative infections and length of hospital stay in elective orthopedic and cardiac surgery. (opens new window)

Llewelyn CA, Taylor RS, Todd AA, Stevens W, Murphy MF, Williamson LM; Leucodepletion Study Group.

Source‎: Transfusion 2004;44(4):489-500.

Indexed‎: PubMed 15043563

DOI‎: 10.1111/j.1537-2995.2004.03325.x

https://www.ncbi.nlm.nih.gov/pubmed/15043563 (opens new window)

Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. (opens new window)

Marik PE, Corwin HL.

Source‎: Crit Care Med 2008;36(9):2667-74.

Indexed‎: PubMed 18679112

DOI‎: 10.1097/CCM.0b013e3181844677

https://www.ncbi.nlm.nih.gov/pubmed/18679112 (opens new window)

Outcomes from cardiac surgery in Jehovah's Witness patients: experience over twenty-one years. (opens new window)

Marinakis S, Van der Linden P, Tortora R, Massaut J, Pierrakos C, Wauthy P.

Source‎: J Cardiothorac Surg 2016;11(1):67.

Indexed‎: PubMed 27079663

DOI‎: 10.1186/s13019-016-0455-6

https://www.ncbi.nlm.nih.gov/pubmed/27079663 (opens new window)

Short term outcomes after cardiac surgery in a Jehovah's Witness population: an institutional experience. (opens new window)

Marshall L, Krampl C, Vrtik M, Haluska B, Griffin R, Mundy J, Shah P.

Source‎: Heart Lung Circ 2012;21(2):101-4.

Indexed‎: PubMed 22047753

DOI‎: 10.1016/j.hlc.2011.10.003

https://www.ncbi.nlm.nih.gov/pubmed/22047753 (opens new window)

Strategies and outcomes of cardiac surgery in Jehovah's Witnesses. (opens new window)

Moraca RJ, Wanamaker KM, Bailey SH, McGregor WE, Benckart DH, Maher TD, Magovern GJ Jr.

Source‎: J Card Surg 2011;26(2):135-43.

Indexed‎: PubMed 21348894

DOI‎: 10.1111/j.1540-8191.2011.01215.x

https://www.ncbi.nlm.nih.gov/pubmed/21348894 (opens new window)

The impact of blood conservation on outcomes in cardiac surgery: is it safe and effective? (opens new window)

Moskowitz DM, McCullough JN, Shander A, Klein JJ, Bodian CA, Goldweit RS, Ergin MA.

Source‎: Ann Thorac Surg 2010;90(2):451-8.

Indexed‎: PubMed 20667328

DOI‎: 10.1016/j.athoracsur.2010.04.089

https://www.ncbi.nlm.nih.gov/pubmed/20667328 (opens new window)

Forum for debate: safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient. [Foro de debate: seguridad de las alternativas a la transfusión alogénica en el paciente quirúrgico y/o crítico.] [English, Spanish] (opens new window)

Muñoz Gómez M, Bisbe Vives E, Basora Macaya M, García Erce JA, Gómez Luque A, Leal-Noval SR, Colomina MJ, Comin Colet J, Contreras Barbeta E, Cuenca Espiérrez J, Garcia de Lorenzo Y Mateos A, Gomollón García F, Izuel Ramí M, Moral García MV, Montoro Ronsano JB, Páramo Fernández JA, Pereira Saavedra A, Quintana Diaz M, Remacha Sevilla Á, Salinas Argente R, Sánchez Pérez C, Tirado Anglés G, Torrabadella de Reinoso P.

Source‎: Med Intensiva 2015;39(9):552-62.

Indexed‎: PubMed 26183121

DOI‎: 10.1016/j.medin.2015.05.006

https://www.ncbi.nlm.nih.gov/pubmed/26183121 (opens new window)

Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. (opens new window)

Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD.

Source‎: Circulation 2007;116(22):2544-52.

Indexed‎: PubMed 17998460

DOI‎: 10.1161/CIRCULATIONAHA.107.698977

https://www.ncbi.nlm.nih.gov/pubmed/17998460 (opens new window)

The association of perioperative transfusion with 30-day morbidity and mortality in patients undergoing major vascular surgery. (opens new window)

Obi AT, Park YJ, Bove P, Cuff R, Kazmers A, Gurm HS, Grossman PM, Henke PK.

Source‎: J Vasc Surg 2015;61(4):1000-9.e1.

Indexed‎: PubMed 25596978

DOI‎: 10.1016/j.jvs.2014.10.106

https://www.ncbi.nlm.nih.gov/pubmed/25596978 (opens new window)

Relationships among haemoglobin level, packed red cell transfusion and clinical outcomes in patients after cardiac surgery. (opens new window)

Oliver E, Carrio ML, Rodríguez-Castro D, Javierre C, Farrero E, Torrado H, Castells E, Ventura JL.

Source‎: Intensive Care Med 2009;35(9):1548-55.

Indexed‎: PubMed 19547956

DOI‎: 10.1007/s00134-009-1526-0

https://www.ncbi.nlm.nih.gov/pubmed/19547956 (opens new window)

Transfusion rate as a quality metric: is blood conservation a learnable skill? (opens new window)

Paone G, Brewer R, Likosky DS, Theurer PF, Bell GF, Cogan CM, Prager RL; Membership of the Michigan Society of Thoracic and Cardiovascular Surgeons.

Source‎: Ann Thorac Surg 2013;96(4):1279-86.

Indexed‎: PubMed 23915586

DOI‎: 10.1016/j.athoracsur.2013.05.045

https://www.ncbi.nlm.nih.gov/pubmed/23915586 (opens new window)

Transfusion of 1 and 2 units of red blood cells is associated with increased morbidity and mortality. (opens new window)

Paone G, Likosky DS, Brewer R, Theurer PF, Bell GF, Cogan CM, Prager RL; Membership of the Michigan Society of Thoracic and Cardiovascular Surgeons.

Source‎: Ann Thorac Surg 2014;97(1):87-94.

Indexed‎: PubMed 24094521

DOI‎: 10.1016/j.athoracsur.2013.07.020

https://www.ncbi.nlm.nih.gov/pubmed/24094521 (opens new window)

Bloodless lung transplantation in Jehovah's Witnesses: impact on perioperative parameters and outcome compared with a matched control group. (opens new window)

Partovi S, Bruckner BA, Staub D, Ortiz G, Scheinin SA, Seethamraju H, Loebe M.

Source‎: Transplant Proc 2013;45(1):335-41.

Indexed‎: PubMed 23267815

DOI‎: 10.1016/j.transproceed.2012.06.057

https://www.ncbi.nlm.nih.gov/pubmed/23267815 (opens new window)

Outcome of patients who refuse transfusion after cardiac surgery: a natural experiment with severe blood conservation. (opens new window)

Pattakos G, Koch CG, Brizzio ME, Batizy LH, Sabik JF 3rd, Blackstone EH, Lauer MS.

Source‎: Arch Intern Med 2012;172(15):1154-60.

Indexed‎: PubMed 22751620

DOI‎: 10.1001/archinternmed.2012.2449

https://www.ncbi.nlm.nih.gov/pubmed/22751620 (opens new window)

Mid-term clinical outcomes in cardiac surgery of Jehovah's Witnesses. (opens new window)

Pompei E, Tursi V, Guzzi G, Vendramin I, Ius F, Muzzi R, Auci E, Badano LP, Livi U.

Source‎: J Cardiovasc Med (Hagerstown) 2010;11(3):170-4.

Indexed‎: PubMed 19934767

DOI‎: 10.2459/JCM.0b013e3283330752

https://www.ncbi.nlm.nih.gov/pubmed/19934767 (opens new window)

Impact of a blood conservation program on 30-day morbidity and mortality: a cohort study. (opens new window)

Ramanan B, Burns TL, Sugimoto JT, Forse RA.

Source‎: J Surg Res 2014;187(1):343-9.

Indexed‎: PubMed 24189177

DOI‎: 10.1016/j.jss.2013.10.005

https://www.ncbi.nlm.nih.gov/pubmed/24189177 (opens new window)

Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. (opens new window)

Ranucci M, Baryshnikova E, Castelvecchio S, Pelissero G; Surgical and Clinical Outcome Research (SCORE) Group.

Source‎: Ann Thorac Surg 2013;96(2):478-85.

Indexed‎: PubMed 23673069

DOI‎: 10.1016/j.athoracsur.2013.03.015

https://www.ncbi.nlm.nih.gov/pubmed/23673069 (opens new window)

Cirugía cardiaca sin sangre en testigos de Jehová: resultados frente a grupo control. Bloodless cardiac surgery in Jehovah's Witnesses: outcomes compared with a control group. [Spanish, English] (opens new window)

Reyes G, Nuche JM, Sarraj A, Cobiella J, Orts M, Martin G, Celemín R, Montalvo E, Martínez-Elbal L, Duarte J.

Source‎: Rev Esp Cardiol 2007;60(7):727-31.

Indexed‎: PubMed 17663857

https://www.ncbi.nlm.nih.gov/pubmed/17663857 (opens new window)

Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. (opens new window)

Rohde JM, Dimcheff DE, Blumberg N, Saint S, Langa KM, Kuhn L, Hickner A, Rogers MA.

Source‎: JAMA 2014;311(13):1317-26.

Indexed‎: PubMed 24691607

DOI‎: 10.1001/jama.2014.2726

https://www.ncbi.nlm.nih.gov/pubmed/24691607 (opens new window)

Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review. (opens new window)

Salpeter SR, Buckley JS, Chatterjee S.

Source‎: Am J Med 2014;127(2):124-131.e3.

Indexed‎: PubMed 24331453

DOI‎: 10.1016/j.amjmed.2013.09.017

https://www.ncbi.nlm.nih.gov/pubmed/24331453 (opens new window)

Heart transplant in Jehovah's Witness patients: a case-control study. (opens new window)

Sander S, Singer-Englar T, Nishihara K, Esmailian F, Patel JK, Kobashigawa JA, Kittleson MM

Source‎: J Heart Lung Transplant 2021;40(7):575-9.

Indexed‎: PubMed 33839007

DOI‎: 10.1016/j.healun.2021.03.014

https://www.ncbi.nlm.nih.gov/pubmed/33839007 (opens new window)

Perioperative anemia and transfusions and late mortality in coronary artery bypass patients. (opens new window)

Schwann TA, Vekstein AM, Engoren M, Grau-Sepulveda M, O'Brien S, Engelman D, Lobdell KW, Gaudino MF, Salenger R, Habib RH

Source‎: Ann Thorac Surg 2023 115(3):759-69.

Indexed‎: PubMed 36574523

DOI‎: 10.1016/j.athoracsur.2022.11.012

https://pubmed.ncbi.nlm.nih.gov/36574523/ (opens new window)

The safety and efficacy of "bloodless" cardiac surgery. (opens new window)

Shander A, Moskowitz D, Rijhwani TS.

Source‎: Semin Cardiothorac Vasc Anesth 2005;9(1):53-63.

Indexed‎: PubMed 15735844

DOI‎: 10.1177/108925320500900106

https://www.ncbi.nlm.nih.gov/pubmed/15735844 (opens new window)

Comparisons of cardiac surgery outcomes in Jehovah's versus non-Jehovah's Witnesses. (opens new window)

Stamou SC, White T, Barnett S, Boyce SW, Corso PJ, Lefrak EA.

Source‎: Am J Cardiol 2006;98(9):1223-5.

Indexed‎: PubMed 17056333

DOI‎: 10.1016/j.amjcard.2006.05.055

https://www.ncbi.nlm.nih.gov/pubmed/17056333 (opens new window)

Outcomes in cardiac surgery in 500 consecutive Jehovah's Witness patients: 21 year experience. (opens new window)

Vaislic CD, Dalibon N, Ponzio O, Ba M, Jugan E, Lagneau F, Abbas P, Olliver Y, Gaillard D, Baget F, Sportiche M, Chedid A, Chaoul G, Maribas P, Dupuy C, Robine B, Kasanin N, Michon H, Ruat JM, Habis M, Bouharaoua T.

Source‎: J Cardiothorac Surg 2012;7:95.

Indexed‎: PubMed 23013647

DOI‎: 10.1186/1749-8090-7-95

https://www.ncbi.nlm.nih.gov/pubmed/23013647 (opens new window)

Outcome of Jehovah's Witnesses after adult cardiac surgery: systematic review and meta-analysis of comparative studies. (opens new window)

Vasques F, Kinnunen EM, Pol M, Mariscalco G, Onorati F, Biancari F.

Source‎: Transfusion 2016;56(8):2146-53.

Indexed‎: PubMed 27197962

DOI‎: 10.1111/trf.13657

https://www.ncbi.nlm.nih.gov/pubmed/27197962 (opens new window)

Transfusion strategies for acute upper gastrointestinal bleeding. (opens new window)

Villanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, Graupera I, Poca M, Alvarez-Urturi C, Gordillo J, Guarner-Argente C, Santaló M, Muñiz E, Guarner C.

Source‎: N Engl J Med 2013;368(1):11-21.

Indexed‎: PubMed 23281973

DOI‎: 10.1056/NEJMoa1211801

https://www.ncbi.nlm.nih.gov/pubmed/23281973 (opens new window)