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Obstetrics

Management and Optimization of Hemostasis

Antifibrinolytic Agents

Effectiveness of tranexamic acid on blood loss in patients undergoing elective cesarean section: randomized clinical trial. (opens new window)

Abdel-Aleem H, Alhusaini TK, Abdel-Aleem MA, Menoufy M, Gülmezoglu AM.

Source‎: J Matern Fetal Neonatal Med 2013;26(17):1705-9.

Indexed‎: PubMed 23574458

https://www.ncbi.nlm.nih.gov/pubmed/23574458 (opens new window)

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients. (opens new window)

Gayet-Ageron A, Prieto-Merino D, Ker K, Shakur H, Ageron FX, Roberts I; Antifibrinolytic Trials Collaboration

Source‎: Lancet 2018;391(10116):125-32.

Indexed‎: PubMed 29126600

DOI‎: 10.1016/S0140-6736(17)32455-8

https://www.ncbi.nlm.nih.gov/pubmed/29126600 (opens new window)

Can intravenous injection of tranexamic acid be used in routine practice with active management of the third stage of labor in vaginal delivery? A randomized controlled study. (opens new window)

Gungorduk K, Asıcıoğlu O, Yıldırım G, Ark C, Tekirdağ Aİ, Besımoglu B.

Source‎: Am J Perinatol 2013;30(5):407-13.

Indexed‎: PubMed 23023559

DOI‎: 10.1055/s-0032-1326986

https://www.ncbi.nlm.nih.gov/pubmed/23023559 (opens new window)

Tranexamic acid for preventing postpartum blood loss after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials. (opens new window)

Simonazzi G, Bisulli M, Saccone G, Moro E, Marshall A, Berghella V.

Source‎: Acta Obstet Gynecol Scand 2016;95(1):28-37.

Indexed‎: PubMed 26698831

DOI‎: 10.1111/aogs.12798

https://www.ncbi.nlm.nih.gov/pubmed/26698831 (opens new window)

Randomized controlled trial of tranexamic acid among parturients at increased risk for postpartum hemorrhage undergoing cesarean delivery. (opens new window)

Sujata N, Tobin R, Kaur R, Aneja A, Khanna M, Hanjoora VM.

Source‎: Int J Gynaecol Obstet 2016;133(3):312-5.

Indexed‎: PubMed 26952346

DOI‎: 10.1016/j.ijgo.2015.09.032

https://www.ncbi.nlm.nih.gov/pubmed/26952346 (opens new window)

Recombinant Activated Factor VII (rFVIIa)

Use of recombinant activated factor VII in primary postpartum hemorrhage: the Northern European registry 2000-2004. (opens new window)

Alfirevic Z, Elbourne D, Pavord S, Bolte A, Van Geijn H, Mercier F, Ahonen J, Bremme K, Bødker B, Magnúsdóttir EM, Salvesen K, Prendiville W, Truesdale A, Clemens F, Piercy D, Gyte G.

Source‎: Obstet Gynecol 2007;110(6):1270-8.

Indexed‎: PubMed 18055720

DOI‎: 10.1097/01.AOG.0000288515.48066.99

https://www.ncbi.nlm.nih.gov/pubmed/18055720 (opens new window)

The use of recombinant activated FVII in postpartum hemorrhage. (opens new window)

Franchini M, Franchi M, Bergamini V, Montagnana M, Salvagno GL, Targher G, Lippi G.

Source‎: Clin Obstet Gynecol 2010;53(1):219-27.

Indexed‎: PubMed 20142658

DOI‎: 10.1097/GRF.0b013e3181cc4378

https://www.ncbi.nlm.nih.gov/pubmed/20142658 (opens new window)

Recombinant human factor VIIa prevents hysterectomy in severe postpartum hemorrhage: single center study. (opens new window)

Huber AW, Raio L, Alberio L, Ghezzi F, Surbek DV.

Source‎: J Perinat Med 2011;40(1):43-9.

Indexed‎: PubMed 22017328

DOI‎: 10.1515/JPM.2011.109

https://www.ncbi.nlm.nih.gov/pubmed/22017328 (opens new window)

Postpartum hemorrhage: when uterotonics and sutures fail. (opens new window)

James AH, McLintock C, Lockhart E.

Source‎: Am J Hematol 2012;87 Suppl 1:S16-22.

Indexed‎: PubMed 22430921

DOI‎: 10.1002/ajh.23156

https://www.ncbi.nlm.nih.gov/pubmed/22430921 (opens new window)

Recombinant activated factor VII (rFVIIa/NovoSeven®) in the management of severe postpartum haemorrhage: initial report of a multicentre case series in Japan. (opens new window)

Kobayashi T, Nakabayashi M, Yoshioka A, Maeda M, Ikenoue T.

Source‎: Int J Hematol 2012;95(1):57-63.

Indexed‎: PubMed 22160834

DOI‎: 10.1007/s12185-011-0974-9

https://www.ncbi.nlm.nih.gov/pubmed/22160834 (opens new window)

Recombinant human FVIIa for reducing the need for invasive second-line therapies in severe refractory postpartum hemorrhage: a multicenter, randomized, open controlled trial. (opens new window)

Lavigne-Lissalde G, Aya AG, Mercier FJ, Roger-Christoph S, Chauleur C, Morau E, Ducloy-Bouthors AS, Mignon A, Raucoules M, Bongain A, Boehlen F, de Moerloose P, Bouvet S, Fabbro-Peray P, Gris JC.

Source‎: J Thromb Haemost 2015;13(4):520-9.

Indexed‎: PubMed 25594352

DOI‎: 10.1111/jth.12844

https://www.ncbi.nlm.nih.gov/pubmed/25594352 (opens new window)

Recombinant factor VIIa after amniotic fluid embolism and disseminated intravascular coagulopathy. (opens new window)

Lim Y, Loo CC, Chia V, Fun W.

Source‎: Int J Gynaecol Obstet 2004;87(2):178-9.

Indexed‎: PubMed 15491576

DOI‎: 10.1016/j.ijgo.2004.08.007

https://www.ncbi.nlm.nih.gov/pubmed/15491576 (opens new window)

Successful treatment of severe intra-abdominal bleeding associated with disseminated intravascular coagulation using recombinant activated factor VII. (opens new window)

Moscardó F, Pérez F, de la Rubia J, Balerdi B, Lorenzo JI, Senent ML, Aznar I, Carceller S, Sanz MA.

Source‎: Br J Haematol 2001;114(1):174-6.

Indexed‎: PubMed 11472364

https://www.ncbi.nlm.nih.gov/pubmed/11472364 (opens new window)

Successful management by recombinant activated factor VII in a case of disseminated intravascular coagulopathy caused by obstetric hemorrhage. (opens new window)

Nohira T, Osakabe Y, Suda S, Takahashi C, Tanaka A, Ikeda K, Ikeda T, Okabe K.

Source‎: J Obstet Gynaecol Res 2008;34(4 Pt 2):623-30.

Indexed‎: PubMed 18840167

https://www.ncbi.nlm.nih.gov/pubmed/18840167 (opens new window)

Recombinant factor VIIa as last-resort treatment of desperate haemorrhage. (opens new window)

Palmason R, Vidarsson B, Sigvaldason K, Ingimarsson JP, Gudbjartsson T, Sigurdsson GH, Onundarson PT.

Source‎: Acta Anaesthesiol Scand 2012;56(5):636-44.

Indexed‎: PubMed 22489992

DOI‎: 10.1111/j.1399-6576.2012.02688.x

https://www.ncbi.nlm.nih.gov/pubmed/22489992 (opens new window)

Factor VIIa in puerperal hemorrhage with disseminated intravascular coagulation. (opens new window)

Pepas LP, Arif-Adib M, Kadir RA.

Source‎: Obstet Gynecol 2006;108(3 Pt 2):757-61.

Indexed‎: PubMed 17018493

DOI‎: 10.1097/01.AOG.0000197064.44340.d4

https://www.ncbi.nlm.nih.gov/pubmed/17018493 (opens new window)

Recombinant activated factor VII in obstetric hemorrhage: experiences from the Australian and New Zealand Haemostasis Registry. (opens new window)

Phillips LE, McLintock C, Pollock W, Gatt S, Popham P, Jankelowitz G, Ogle R, Cameron PA; Australian and New Zealand Haemostasis Registry.

Source‎: Anesth Analg 2009;109(6):1908-15.

Indexed‎: PubMed 19923520

DOI‎: 10.1213/ANE.0b013e3181c039e6

https://www.ncbi.nlm.nih.gov/pubmed/19923520 (opens new window)

Recombinant factor VIIa to successfully manage disseminated intravascular coagulation from amniotic fluid embolism. (opens new window)

Prosper SC, Goudge CS, Lupo VR.

Source‎: Obstet Gynecol 2007;109(2 Pt2):524-5.

Indexed‎: PubMed 17267882

DOI‎: 10.1097/01.AOG.0000235711.11817.8c

https://www.ncbi.nlm.nih.gov/pubmed/17267882 (opens new window)

Coagulation Factor Concentrates

The efficacy of fibrinogen concentrate compared with cryoprecipitate in major obstetric haemorrhage--an observational study. (opens new window)

Ahmed S, Harrity C, Johnson S, Varadkar S, McMorrow S, Fanning R, Flynn CM, O'Riordan JM, Byrne BM.

Source‎: Transfus Med 2012;22(5):344-9.

Indexed‎: PubMed 22994449

https://www.ncbi.nlm.nih.gov/pubmed/22994449 (opens new window)

The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage. (opens new window)

Bell SF, Rayment R, Collins PW, Collis RE.

Source‎: Int J Obstet Anesth 2010;19(2):218-23.

Indexed‎: PubMed 20194010

DOI‎: 10.1016/j.ijoa.2009.08.004

https://www.ncbi.nlm.nih.gov/pubmed/20194010 (opens new window)

Association between fibrinogen level and severity of postpartum haemorrhage: secondary analysis of a prospective trial. (opens new window)

Cortet M, Deneux-Tharaux C, Dupont C, Colin C, Rudigoz RC, Bouvier-Colle MH, Huissoud C.

Source‎: Br J Anaesth 2012;108(6):984-9.

Indexed‎: PubMed 22490316

DOI‎: 10.1093/bja/aes096

https://www.ncbi.nlm.nih.gov/pubmed/22490316 (opens new window)

Association between fibrinogen levels and severity of postpartum hemorrhage in singleton vaginal deliveries at a Japanese perinatal center. (opens new window)

Shibata Y, Shigemi D, Ito M, Terada K, Nakanishi K, Kato M, Igarashi M, Suzuki S.

Source‎: J Nippon Med Sch 2014;81(2):94-6.

Indexed‎: PubMed 24805095

https://www.ncbi.nlm.nih.gov/pubmed/24805095 (opens new window)

Desmopressin

A systematic review: the use of desmopressin for treatment and prophylaxis of bleeding disorders in pregnancy. (opens new window)

Trigg DE, Stergiotou I, Peitsidis P, Kadir RA.

Source‎: Haemophilia 2012;18(1):25-33.

Indexed‎: PubMed 21624012

DOI‎: 10.1111/j.1365-2516.2011.02573.x

https://www.ncbi.nlm.nih.gov/pubmed/21624012 (opens new window)

Topical Hemostatic Agents

Tisseel for management of traumatic postpartum haemorrhage. (opens new window)

Dhulkotia JS, Alazzam M, Galimberti A.

Source‎: Arch Gynecol Obstet 2009;279(3):437-9.

Indexed‎: PubMed 18985368

DOI‎: 10.1007/s00404-008-0824-z

https://www.ncbi.nlm.nih.gov/pubmed/18985368 (opens new window)

Uterine packing with chitosan-covered tamponade to treat postpartum hemorrhage. (opens new window)

Henrich W, Dückelmann A, Braun T, Hinkson L

Source‎: Am J Obstet Gynecol 2024;230(3S):S1061-65.

Indexed‎: PubMed 38462249

DOI‎: 10.1016/j.ajog.2022.11.1297

https://pubmed.ncbi.nlm.nih.gov/38462249/ (opens new window)

Use of FloSeal haemostatic gel in massive obstetric haemorrhage: a case report. (opens new window)

Moriarty KT, Premila S, Bulmer PJ.

Source‎: BJOG 2008;115(6):793-5.

Indexed‎: PubMed 18355369

DOI‎: 10.1111/j.1471-0528.2007.01654.x

https://www.ncbi.nlm.nih.gov/pubmed/18355369 (opens new window)

Topical application of recombinant activated factor VII during cesarean delivery for placenta previa. (opens new window)

Schjoldager BTBG, Mikkelsen E, Lykke MR, Præst J, Hvas AM, Heslet L, Secher NJ, Salvig JD, Uldbjerg N

Source‎: Am J Obstet Gynecol 2017;216(6):608.e1-5.

Indexed‎: PubMed 28219621

DOI‎: 10.1016/j.ajog.2017.02.024

https://www.ncbi.nlm.nih.gov/pubmed/28219621 (opens new window)

Fibrin sealant for management of complicated obstetric lacerations. (opens new window)

Whiteside JL, Asif RB, Novello RJ.

Source‎: Obstet Gynecol 2010;115(2 Pt 2):403-4.

Indexed‎: PubMed 20093858

DOI‎: 10.1097/AOG.0b013e3181bb1e28

https://www.ncbi.nlm.nih.gov/pubmed/20093858 (opens new window)

Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Assessment of coagulation in the obstetric population using ROTEM® thromboelastometry. (opens new window)

Armstrong S, Fernando R, Ashpole K, Simons R, Columb M.

Source‎: Int J Obstet Anesth 2011;20(4):293-8.

Indexed‎: PubMed 21835606

https://www.ncbi.nlm.nih.gov/pubmed/21835606 (opens new window)

Obstetric hemorrhage and coagulation: an update. Thromboelastography, thromboelastometry, and conventional coagulation tests in the diagnosis and prediction of postpartum hemorrhage. (opens new window)

de Lange NM, Lancé MD, de Groot R, Beckers EA, Henskens YM, Scheepers HC.

Source‎: Obstet Gynecol Surv 2012;67(7):426-35.

Indexed‎: PubMed 22926249

DOI‎: 10.1097/OGX.0b013e3182605861

https://www.ncbi.nlm.nih.gov/pubmed/22926249 (opens new window)

Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. (opens new window)

Levy JH, Welsby I, Goodnough LT.

Source‎: Transfusion 2014;54(5):1389-405.

Indexed‎: PubMed 24117955

DOI‎: 10.1111/trf.12431

https://www.ncbi.nlm.nih.gov/pubmed/24117955 (opens new window)

Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy. (opens new window)

McNamara H, Mallaiah S, Barclay P, Chevannes C, Bhalla A.

Source‎: Int J Obstet Anesth 2015;24(2):174-9.

Indexed‎: PubMed 25659517

https://www.ncbi.nlm.nih.gov/pubmed/25659517 (opens new window)

Haemostatic monitoring during postpartum haemorrhage and implications for management. (opens new window)

Solomon C, Collis RE, Collins PW.

Source‎: Br J Anaesth 2012;109(6):851-63.

Indexed‎: PubMed 23075633

DOI‎: 10.1093/bja/aes361

https://www.ncbi.nlm.nih.gov/pubmed/23075633 (opens new window)